1.やさしい
What does pharmacokinetics describe?
- AHow drugs are manufactured and packaged
- BHow the price of a drug is set
- CWhat a drug does to the body: its effects, receptors and mechanisms of action
- DWhat the body does to a drug: absorption, distribution, metabolism and excretion
2.やさしい
What is the purpose of the Z-track technique for intramuscular injections?
- ATo stop the drug leaking back into the subcutaneous tissue
- BTo make the injection faster
- CTo avoid the need to clean the skin
- DTo allow a larger volume to be given than with a standard injection
3.やさしい
How does ezetimibe lower cholesterol?
- AIt increases the excretion of cholesterol in the urine and bile
- BIt binds bile acids in the gut
- CIt inhibits HMG-CoA reductase in the liver
- DIt reduces the absorption of cholesterol from the intestine
4.ふつう
Which description fits tardive dyskinesia?
- AA low white cell count with sore throat and fever
- BInvoluntary movements of the lips, tongue and face after long-term antipsychotic use
- CHigh fever with lead-pipe rigidity and confusion
- DA sudden painful spasm of the neck muscles and upward rolling of the eyes within days of the first dose
5.ふつう
経口ステロイドの長期使用でよく知られた副作用はどれですか?
- A低血糖
- B体重減少
- C低血圧
- D骨粗鬆症
6.ふつう
A patient receiving chemotherapy has a very low neutrophil count and is going home. Which teaching is most important?
- AExercise in crowded gyms to build strength
- BReport a temperature of 38 °C (100.4 °F) or higher straight away
- CTake paracetamol regularly so that fevers do not show
- DEat plenty of raw shellfish to boost protein
7.むずかしい
Why is vancomycin given by mouth, not intravenously, for Clostridioides difficile infection?
- AOral vancomycin is absorbed into the blood better than IV vancomycin
- BOral vancomycin is not absorbed, so it reaches high levels in the colon
- CIntravenous vancomycin causes C. difficile infection
- DThe oral form is cheaper but has the same effect as IV
8.むずかしい
A man taking spironolactone for heart failure develops painful breast enlargement. Which change may be considered?
- AAdding testosterone injections
- BDoubling the spironolactone dose to overcome the side effect
- CSwitching to potassium chloride tablets
- DSwitching to eplerenone, which has fewer anti-androgen effects
解答
- 1. D · What the body does to a drug: absorption, distribution, metabolism and excretion
- 2. A · To stop the drug leaking back into the subcutaneous tissue
- 3. D · It reduces the absorption of cholesterol from the intestine
- 4. B · Involuntary movements of the lips, tongue and face after long-term antipsychotic use
- 5. D · 骨粗鬆症
- 6. B · Report a temperature of 38 °C (100.4 °F) or higher straight away
- 7. B · Oral vancomycin is not absorbed, so it reaches high levels in the colon
- 8. D · Switching to eplerenone, which has fewer anti-androgen effects
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