解答つき薬理学ワークシート

無料で印刷できる薬理学のワークシート：やさしい問題から試験レベルまで 8 問、解答つき。印刷するか PDF で保存できます。

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名前: ____________________   日付: ____________

1.やさしい

新薬が通常、初めてヒト（多くは健康な志願者）に投与されるのは臨床試験のどの相ですか？

  1. A第 I 相
  2. B第 II 相
  3. C第 III 相
  4. D第 IV 相
2.やさしい

オンダンセトロンは主に何の治療に使いますか？

  1. A便秘
  2. B細菌感染症
  3. C高血圧
  4. D吐き気と嘔吐
3.やさしい

Stimulation of which receptor increases heart rate and the force of contraction?

  1. AAlpha-2 adrenergic receptor
  2. BBeta-1 adrenergic receptor
  3. CMuscarinic M2 receptor
  4. DBeta-2 adrenergic receptor
4.ふつう

Why are patients taking simvastatin often advised to avoid large amounts of grapefruit juice?

  1. AGrapefruit speeds up simvastatin breakdown in the liver, so the drug stops working
  2. BGrapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
  3. CGrapefruit blocks cholesterol absorption and causes low cholesterol
  4. DGrapefruit makes the tablet dissolve in the mouth
5.ふつう

A patient wants to stop paroxetine suddenly. What should the nurse explain?

  1. AStopping suddenly causes dangerous low blood sugar
  2. BIt can be stopped at any time, as antidepressants cause no withdrawal effects
  3. CStopping suddenly causes the drug to work better for a while
  4. DIt can cause dizziness, "electric shock" feelings and irritability
6.ふつう

A man taking tamsulosin is planning cataract surgery. What should the nurse advise?

  1. ATake a double dose on the day of surgery
  2. BStop the drug for one day and no further action is needed
  3. CThe drug has no link with eye surgery
  4. DTell the eye surgeon, as it can cause floppy iris syndrome
7.むずかしい

A patient on weekly methotrexate is prescribed trimethoprim for a urinary infection. What is the main risk?

  1. ALoss of antibiotic effect because methotrexate binds trimethoprim
  2. BHypoglycaemia from reduced liver glucose output
  3. CBone marrow suppression, because both drugs inhibit folate metabolism
  4. DSevere hypertension from the combination
8.むずかしい

A patient with severe chronic hyponatraemia receives hypertonic saline. Why is the rate of correction strictly limited?

  1. AHypertonic saline is toxic to the liver at high rates
  2. BRaising sodium too fast causes severe hypokalaemia and cardiac arrest
  3. CFast correction causes immediate kidney failure
  4. DRaising sodium too fast can cause osmotic demyelination in the brain

解答

  1. 1. A · 第 I 相
  2. 2. D · 吐き気と嘔吐
  3. 3. B · Beta-1 adrenergic receptor
  4. 4. B · Grapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
  5. 5. D · It can cause dizziness, "electric shock" feelings and irritability
  6. 6. D · Tell the eye surgeon, as it can cause floppy iris syndrome
  7. 7. C · Bone marrow suppression, because both drugs inhibit folate metabolism
  8. 8. D · Raising sodium too fast can cause osmotic demyelination in the brain

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