1.やさしい
How does allopurinol prevent gout?
- AIt blocks prostaglandins in the inflamed joint
- BIt increases the kidney excretion of calcium
- CIt inhibits xanthine oxidase, so less uric acid is made
- DIt dissolves crystals already in the joint within hours
2.やさしい
薬物耐性(トレランス)とは何ですか?
- A繰り返し使ううちに反応が弱まり、より多い用量が必要になること
- B薬を使うたびに反応が強くなること
- C薬に対するアレルギー反応
- D副作用がまったく出ずに薬を使える能力
3.やさしい
What is a prodrug?
- AA drug that is given before surgery
- BA drug that has passed all clinical trials
- CA drug that is inactive until the body converts it into its active form
- DA drug that prevents or reverses the effect of another drug in the body
4.ふつう
Why is a spacer recommended with a metered-dose inhaler?
- AIt turns the inhaler into a nebuliser
- BMore drug reaches the lungs and less stays in the mouth
- CIt removes the need to shake the inhaler
- DIt doubles the dose of drug released by each puff of the inhaler
5.ふつう
A patient takes regular paracetamol (acetaminophen) at home. Which teaching point best prevents accidental overdose?
- AUse paracetamol only on an empty stomach
- BTake paracetamol with alcohol to improve absorption
- CCheck cold and flu remedies, as many also contain paracetamol
- DTake an extra dose if the first one does not work within 10 minutes
6.ふつう
A patient with a peanut allergy is taught to use an adrenaline auto-injector. Which statement is correct?
- AUse it only if the antihistamine has not worked after an hour
- BThere is no need to see a doctor if the swelling goes down
- CCall emergency services after using it, even if symptoms improve
- DKeep it at home so it is not lost
7.むずかしい
An older patient on amlodipine develops ankle swelling and is prescribed furosemide. She then becomes dizzy and falls. What does this sequence illustrate?
- AEnzyme induction
- BDrug tolerance
- CA prescribing cascade
- DA type B allergic reaction
8.むずかしい
A postoperative patient using morphine PCA is very drowsy, hard to rouse and has a respiratory rate of 7 per minute. What should the nurse do first?
- AReduce the PCA dose and leave the pump running
- BLet the patient sleep and recheck in one hour
- CStop the PCA, try to rouse the patient and give naloxone as per protocol
- DEncourage the patient to press the button only when awake and in pain
解答
- 1. C · It inhibits xanthine oxidase, so less uric acid is made
- 2. A · 繰り返し使ううちに反応が弱まり、より多い用量が必要になること
- 3. C · A drug that is inactive until the body converts it into its active form
- 4. B · More drug reaches the lungs and less stays in the mouth
- 5. C · Check cold and flu remedies, as many also contain paracetamol
- 6. C · Call emergency services after using it, even if symptoms improve
- 7. C · A prescribing cascade
- 8. C · Stop the PCA, try to rouse the patient and give naloxone as per protocol
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