1.やさしい
Which of these is an extrapyramidal side effect of antipsychotics?
- ADry mouth
- BAgranulocytosis (a very low neutrophil count)
- CAkathisia (a feeling of inner restlessness)
- DWeight gain
2.やさしい
Which long-term side effect of phenytoin makes good oral hygiene especially important?
- ABlue-grey discoloration of the teeth and gums
- BLoss of taste
- CExcess saliva production
- DOvergrowth of the gums (gingival hyperplasia)
3.やさしい
What is enzyme induction?
- AA drug causes an allergic reaction to enzymes
- BA drug blocks liver enzymes, so other drugs build up in the blood
- CA drug speeds up liver enzymes, so other drugs are broken down faster
- DA drug is converted into an enzyme in the body
4.ふつう
エンパグリフロジンなどの SGLT2 阻害薬はどのように血糖を下げますか?
- A肝臓がより多くのグリコーゲンを蓄えるようにする
- B尿中へのブドウ糖の排出を増やす
- C胃の排出を遅くする
- Dβ細胞からのインスリン分泌を刺激する
5.ふつう
メトロニダゾールを服用する患者が通常避けるよう勧められるものは何ですか?
- Aアルコール
- B日光
- C乳製品
- Dグレープフルーツジュース
6.ふつう
Why is testing for HLA-B*15:02 recommended before carbamazepine in people of some Asian ancestries?
- AIt greatly raises the risk of Stevens–Johnson syndrome
- BThis gene variant causes carbamazepine to raise blood glucose
- CThis gene variant speeds up the kidney excretion of carbamazepine
- DThis gene variant makes carbamazepine ineffective
7.むずかしい
A postoperative patient using morphine PCA is very drowsy, hard to rouse and has a respiratory rate of 7 per minute. What should the nurse do first?
- AStop the PCA, try to rouse the patient and give naloxone as per protocol
- BLet the patient sleep and recheck in one hour
- CEncourage the patient to press the button only when awake and in pain
- DReduce the PCA dose and leave the pump running
8.むずかしい
A patient taking warfarin asks for something for a headache. Which drug is usually the safest choice?
- AIbuprofen, at the lowest dose
- BParacetamol (acetaminophen)
- CAspirin
- DNaproxen
解答
- 1. C · Akathisia (a feeling of inner restlessness)
- 2. D · Overgrowth of the gums (gingival hyperplasia)
- 3. C · A drug speeds up liver enzymes, so other drugs are broken down faster
- 4. B · 尿中へのブドウ糖の排出を増やす
- 5. A · アルコール
- 6. A · It greatly raises the risk of Stevens–Johnson syndrome
- 7. A · Stop the PCA, try to rouse the patient and give naloxone as per protocol
- 8. B · Paracetamol (acetaminophen)
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