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Nama: ____________________ Tarikh: ____________
1.Mudah
How does rasagiline help in Parkinson's disease?
AIt is converted directly into dopamine inside brain neurones
BIt blocks acetylcholine receptors in the gut
CIt blocks dopamine receptors in the brain
DIt inhibits MAO-B, so brain dopamine is broken down more slowly
2.Mudah
Which drug is used as an antidote for cyanide poisoning?
AProtamine sulfate
BDeferoxamine
CHydroxocobalamin
DVitamin K
3.Mudah
Dalam fasa ujian klinikal yang mana ubat baharu biasanya mula-mula diberi kepada manusia, sering sukarelawan sihat?
AFasa II
BFasa III
CFasa IV
DFasa I
4.Sederhana
A person who has never been vaccinated against tetanus has a deep, dirty wound. What is usually given?
ANo treatment unless symptoms appear
BTetanus vaccine only, after the wound heals
COral antibiotics only
DTetanus vaccine and tetanus immunoglobulin
5.Sederhana
A patient is due the first dose of IV cefuroxime. Which question is most important before giving it?
A"Do you prefer the drip in your left arm or in your right arm?"
B"Have you ever had a reaction to penicillin or another antibiotic?"
C"Have you taken paracetamol today?"
D"Have you eaten anything in the last two hours?"
6.Sederhana
Reseptor manakah yang terutamanya disekat oleh penyekat beta seperti metoprolol?
AReseptor muskarinik di jantung
BReseptor adrenergik beta-1 di jantung
CReseptor beta-3 dalam tisu lemak
DReseptor alfa-1 dalam saluran darah
7.Sukar
Pelepasan sesuatu ubat jatuh separuh akibat kegagalan buah pinggang, manakala isi padu pengagihannya kekal sama. Apakah yang berlaku kepada separuh hayatnya?
AIa menjadi separuh
BIa meningkat empat kali ganda
CIa berganda
DIa kekal sama
8.Sukar
A malnourished patient with low serum albumin shows nystagmus and unsteady gait. Her total phenytoin level is within range. What is the most likely explanation?
ALow albumin speeds up phenytoin metabolism
BLow albumin makes phenytoin bind more tightly, so the drug is less active
CThe total level is high, but the laboratory is wrong
DMore phenytoin is unbound when albumin is low, so free levels rise
Kunci jawapan
1. D · It inhibits MAO-B, so brain dopamine is broken down more slowly
2. C · Hydroxocobalamin
3. D · Fasa I
4. D · Tetanus vaccine and tetanus immunoglobulin
5. B · "Have you ever had a reaction to penicillin or another antibiotic?"
6. B · Reseptor adrenergik beta-1 di jantung
7. C · Ia berganda
8. D · More phenytoin is unbound when albumin is low, so free levels rise
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