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Naam: ____________________ Datum: ____________
1.Makkelijk
Wat is een bijwerking (adverse drug reaction)?
AElk effect van een middel dat de patiënt opmerkt
BEen schadelijke, onbedoelde reactie op een middel bij normale doses
CHet beoogde therapeutische effect van een middel
DEen reactie die alleen na een overdosis optreedt
2.Makkelijk
Finasteride is used in benign prostatic hyperplasia because it:
AInhibits 5-alpha reductase and slowly shrinks the prostate
BKills bacteria in the prostate
CRelaxes smooth muscle in the prostate within hours of the first dose
DIncreases testosterone production
3.Makkelijk
Celecoxib selectively inhibits which enzyme?
ACyclo-oxygenase-2 (COX-2)
BLipoxygenase
CCyclo-oxygenase-1 (COX-1)
DPhospholipase A2
4.Gemiddeld
A patient takes low-dose weekly methotrexate for rheumatoid arthritis. Which monitoring is needed?
ARegular blood count, liver and kidney function tests
BWeekly INR checks and a monthly ECG to check the heart rhythm
CDaily blood glucose checks
DMonthly hearing tests
5.Gemiddeld
Which approach is usually recommended to prevent constipation in a patient on regular opioids?
ANo laxative until the patient has not opened the bowels for a week
BA stimulant laxative such as senna, often with a stool softener
CBulk-forming fibre alone, with fluid intake restricted
DAn antidiarrhoeal drug at night to slow the gut
6.Gemiddeld
A patient takes cholestyramine. How should other oral medicines be timed?
ATiming does not matter, as cholestyramine is not absorbed
BTake them all at the same time as cholestyramine
CMix them into the cholestyramine drink so they are taken together
DTake them 1 hour before or several hours after cholestyramine
7.Moeilijk
A patient took a doxycycline tablet with a sip of water just before lying down. Now swallowing is very painful. What is the most likely cause?
AGastric ulcer caused by doxycycline
BPill-induced oesophagitis
COral candidiasis from the antibiotic
DAn allergic reaction to the tablet coating
8.Moeilijk
A patient starting sertraline is taught about the drug. Which statement shows a need for further teaching?
A"If I feel better after a week, I can stop taking it."
B"I may have some nausea at first."
C"I will tell someone if I have thoughts of harming myself."
D"It may take a few weeks to feel the full effect."
Antwoordenblad
1. B · Een schadelijke, onbedoelde reactie op een middel bij normale doses
2. A · Inhibits 5-alpha reductase and slowly shrinks the prostate
3. A · Cyclo-oxygenase-2 (COX-2)
4. A · Regular blood count, liver and kidney function tests
5. B · A stimulant laxative such as senna, often with a stool softener
6. D · Take them 1 hour before or several hours after cholestyramine
7. B · Pill-induced oesophagitis
8. A · "If I feel better after a week, I can stop taking it."
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