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Naam: ____________________ Datum: ____________
1.Makkelijk
Welk orgaan scheidt de meeste wateroplosbare geneesmiddelen en hun metabolieten uit?
ANier
BHuid
CLever
DLong
2.Makkelijk
How does tramadol relieve pain?
AAntagonising NMDA receptors in the spinal cord and blocking sodium channels
BBlocking COX enzymes in the periphery
CWeak opioid agonism plus inhibiting the reuptake of serotonin and noradrenaline
DBlocking sodium channels in peripheral nerves
3.Makkelijk
Which intramuscular site is generally preferred for adults because it is far from major nerves and vessels?
AVentrogluteal
BForearm
CDorsogluteal
DDeltoid for large volumes
4.Gemiddeld
How should a hyoscine (scopolamine) patch for motion sickness be used?
AApply it to the chest only after the vomiting has started
BApply it behind the ear several hours before travel
CSwallow it if no water is available
DCut it in half for children without advice
5.Gemiddeld
After instilling eye drops, why should the patient press gently on the inner corner of the eye for a minute or two?
ATo make the pupil dilate faster
BTo stop the eye from producing tears for about an hour
CTo reduce drainage into the nose and absorption into blood
DTo spread the drop evenly over the eyelid
6.Gemiddeld
A parent will give a liquid medicine to a child at home. Which advice is safest?
AEstimate the dose by pouring the liquid into a small cup
BMix the dose into a full bottle of milk
CUse any kitchen teaspoon
DUse the oral syringe or measuring cup supplied with it
7.Moeilijk
Pasgeborenen die chlooramfenicol krijgen, kunnen het "grey baby syndrome" ontwikkelen. Wat is de belangrijkste reden?
AEen onrijpe glucuronidering in de lever laat het middel stapelen
BDe nier van de pasgeborene scheidt het middel te snel uit, dus er worden hogere doses gegeven
CPasgeborenen maken antistoffen tegen het middel
DChlooramfenicol wordt bij neonaten omgezet in vitamine K
8.Moeilijk
A woman with epilepsy who takes an antiepileptic drug plans to become pregnant. Which advice is standard?
AAvoid folic acid because it lowers drug levels
BStop all antiepileptic drugs straight away as soon as she stops contraception
CTake folic acid before conception and seek specialist review of her medication
DNo change is needed, as antiepileptics carry no risk in pregnancy
Antwoordenblad
1. A · Nier
2. C · Weak opioid agonism plus inhibiting the reuptake of serotonin and noradrenaline
3. A · Ventrogluteal
4. B · Apply it behind the ear several hours before travel
5. C · To reduce drainage into the nose and absorption into blood
6. D · Use the oral syringe or measuring cup supplied with it
7. A · Een onrijpe glucuronidering in de lever laat het middel stapelen
8. C · Take folic acid before conception and seek specialist review of her medication
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