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Naam: ____________________ Datum: ____________
1.Makkelijk
Montelukast, used in asthma, belongs to which drug class?
AAntimuscarinic bronchodilators
BInhaled corticosteroids
CShort-acting beta-2 agonists
DLeukotriene receptor antagonists
2.Makkelijk
Why is folinic acid (leucovorin) given after high-dose methotrexate?
ATo protect normal cells from methotrexate toxicity
BTo make methotrexate act faster on the tumour
CTo prevent nausea and vomiting after the methotrexate
DTo treat an allergic reaction to methotrexate
3.Makkelijk
What does "bacteriostatic" mean?
AThe drug kills viruses as well as bacteria
BThe drug prevents the patient's immune response
CThe drug stops bacteria multiplying without killing them directly
DThe drug kills bacteria directly by breaking down their cell wall
4.Gemiddeld
A patient is starting lamotrigine. Which adverse effect should the patient report at once?
AAny new skin rash
BA brief change in taste
CMild headache on the first day
DSlight tiredness in the afternoon
5.Gemiddeld
After instilling eye drops, why should the patient press gently on the inner corner of the eye for a minute or two?
ATo make the pupil dilate faster
BTo reduce drainage into the nose and absorption into blood
CTo stop the eye from producing tears for about an hour
DTo spread the drop evenly over the eyelid
6.Gemiddeld
Before starting a TNF-alpha inhibitor such as adalimumab, which test is required?
AScreening for latent tuberculosis
BA glucose tolerance test
CAn echocardiogram in every patient
DA bone density scan
7.Moeilijk
A patient with severe liver cirrhosis needs a benzodiazepine for alcohol withdrawal. Why is lorazepam often chosen instead of diazepam?
ALorazepam is a stronger anticonvulsant than all other benzodiazepines
BLorazepam does not cause sedation in liver disease
CLorazepam is excreted unchanged in the urine without any metabolism
DLorazepam is cleared by simple conjugation and has no active metabolites
8.Moeilijk
Pasgeborenen die chlooramfenicol krijgen, kunnen het "grey baby syndrome" ontwikkelen. Wat is de belangrijkste reden?
AChlooramfenicol wordt bij neonaten omgezet in vitamine K
BDe nier van de pasgeborene scheidt het middel te snel uit, dus er worden hogere doses gegeven
CEen onrijpe glucuronidering in de lever laat het middel stapelen
DPasgeborenen maken antistoffen tegen het middel
Antwoordenblad
1. D · Leukotriene receptor antagonists
2. A · To protect normal cells from methotrexate toxicity
3. C · The drug stops bacteria multiplying without killing them directly
4. A · Any new skin rash
5. B · To reduce drainage into the nose and absorption into blood
6. A · Screening for latent tuberculosis
7. D · Lorazepam is cleared by simple conjugation and has no active metabolites
8. C · Een onrijpe glucuronidering in de lever laat het middel stapelen
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