Learn Biology for nursing entrance exams from scratch
1Cells and their parts
The cell theory says that all living things are made of cells, the cell is the basic unit of life, and every cell comes from an existing cell.
Prokaryotes (bacteria) have no nucleus: their DNA lies in the cytoplasm. Eukaryotes (plants, animals, fungi) keep their DNA in a nucleus and have membrane-bound organelles.
- Nucleus: stores DNA and controls the cell.
- Mitochondria: aerobic respiration, most of the cell’s ATP.
- Ribosomes: build proteins; on the rough ER they make proteins for export.
- Golgi apparatus: modifies, sorts and packages proteins.
- Lysosomes: digest waste with enzymes.
- Plant cells also have a cell wall (cellulose), chloroplasts (photosynthesis) and a large vacuole.
Self-check Which organelle would be most plentiful in a muscle cell that uses a lot of energy?
- Cell wall
- Chloroplasts
- Lysosomes
- Mitochondria
Answer: Mitochondria. Mitochondria release most of the cell’s ATP. Chloroplasts and cell walls belong to plant cells, and lysosomes digest waste rather than supply energy.
2Moving things in and out of cells
The cell membrane is a phospholipid bilayer with proteins in it. It is selectively permeable.
- Diffusion: particles move from high to low concentration, without energy.
- Osmosis: diffusion of water across a membrane, towards the side with more dissolved particles.
- Facilitated diffusion: down the gradient through channel or carrier proteins, no ATP.
- Active transport: against the gradient, using ATP (for example the sodium-potassium pump).
A red blood cell in a hypertonic solution (saltier outside) shrinks; in a hypotonic solution (pure water) it swells and may burst; in an isotonic solution it stays the same.
Self-check A cell is placed in a solution that has more dissolved salt than its cytoplasm. What happens?
- Nothing happens because water cannot cross membranes
- Salt leaves the cell and it swells
- Water enters the cell and it bursts
- Water leaves the cell and it shrinks
Answer: Water leaves the cell and it shrinks. Water moves by osmosis towards the side with more solute, so it leaves the cell. Swelling would happen in a hypotonic solution, the opposite situation.
3Cell division and DNA
Mitosis makes two identical diploid cells for growth and repair: prophase, metaphase (chromosomes line up in the middle), anaphase (chromatids pulled apart), telophase. DNA is copied earlier, in the S phase of interphase.
Meiosis makes four genetically different haploid gametes (23 chromosomes in humans) through two divisions. Crossing over in prophase I mixes alleles.
DNA is a double helix of nucleotides with the bases A, T, G and C. A pairs with T and G with C. RNA is single-stranded and uses uracil (U) instead of thymine.
Protein synthesis: transcription copies a gene into mRNA in the nucleus; translation at the ribosome reads mRNA codons (three bases each) and joins amino acids.
DNA template TAC → mRNA AUG → tRNA anticodon UAC
Self-check Which process produces egg and sperm cells with 23 chromosomes?
- Binary fission
- Meiosis
- Mitosis
- Transcription
Answer: Meiosis. Meiosis halves the chromosome number. Mitosis keeps all 46, binary fission is how bacteria divide, and transcription makes RNA, not cells.
4Genetics and inheritance
Each person has two alleles of each gene, one from each parent. A dominant allele (A) shows even with one copy; a recessive allele (a) shows only as aa. AA and aa are homozygous; Aa is heterozygous. The genotype is the alleles; the phenotype is the trait you see.
Use a Punnett square. Aa × Aa gives 1 AA : 2 Aa : 1 aa, a 3 : 1 phenotype ratio. Aa × aa gives 1 : 1.
Special cases: incomplete dominance blends (red × white → pink); codominance shows both (blood type AB); X-linked recessive traits such as haemophilia are more common in males, who have one X.
Worked exampleTwo parents who are both Aa have a child. What is the chance that the child shows the recessive trait?
1Each parent gives A or a, each with probability ½.
2The four equally likely cells are AA, Aa, aA and aa.
3Only aa shows the recessive trait: 1 of 4 cells.
5Molecules of life and microorganisms
- Carbohydrates: sugars (glucose) and polysaccharides (starch, glycogen, cellulose); quick energy.
- Lipids: fats, oils, phospholipids, steroids; long-term energy (about 9 kcal/g) and membranes.
- Proteins: chains of amino acids joined by peptide bonds; enzymes, structure, transport.
- Nucleic acids: DNA and RNA, made of nucleotides.
Enzymes are protein catalysts that lower the activation energy. Each fits its substrate at the active site; heat or a wrong pH changes the shape (denaturation) and stops it working.
Bacteria are prokaryotic cells that divide by binary fission and can be treated with antibiotics. Viruses are DNA or RNA in a protein coat; they need a host cell and are not affected by antibiotics. Fungi include yeasts and moulds.
Self-check Why do antibiotics not work against the common cold?
- Antibiotics only work on the skin
- Colds are caused by bacteria that are too small to reach
- Colds are caused by viruses, which lack the structures antibiotics attack
- The cold virus is a type of fungus
Answer: Colds are caused by viruses, which lack the structures antibiotics attack. Antibiotics target bacterial cell walls, ribosomes and enzymes. Viruses have none of these, so antibiotics cannot stop them.
6Scientific reasoning
A hypothesis is a testable prediction (“If plants get more light, then they grow taller”). The independent variable is what you change; the dependent variable is what you measure; controlled variables stay the same. A control group gives a baseline.
Good experiments use large samples, repeat measurements, random assignment and, in trials, placebos and double blinding. Results support a hypothesis but never prove it absolutely.
Correlation is not causation: two things can rise together because a third factor drives both.
Self-check Students test how the amount of fertiliser affects plant height. What is the dependent variable?
- Amount of fertiliser
- Amount of water
- Plant height
- Type of soil
Answer: Plant height. Height is measured, so it is the dependent variable. Fertiliser is the independent variable, and soil and water should be controlled.
7How exam questions look
- Easy (key terms and facts): organelles and their jobs, DNA bases, what diffusion and osmosis are, the parts of an experiment.
- Medium (applying the concepts): cells in hypertonic or hypotonic solutions, phases of mitosis, simple Punnett squares, transcription and translation, enzymes and temperature.
- Hard (cases and analysis): dihybrid and X-linked crosses, blood types, Chargaff’s rule, frameshift mutations, judging the design and conclusions of a study.
Read every option before choosing: the wrong answers are often true statements that do not answer the question asked.
Learn it step by step in the appLearn it step by step in the app