Фармакология: лист заданий с ответами

Какая из этих реакций является типичной реакцией II фазы (конъюгации) метаболизма лекарств?

1. AВосстановление
2. BГлюкуронирование
3. CОкисление
4. DГидролиз

Which drug can be used in beta blocker overdose because it raises heart rate through a non-adrenergic pathway?

1. AFlumazenil
2. BInsulin
3. CGlucagon
4. DNaloxone

Fluconazole is used to treat infections caused by:

1. AViruses such as influenza
2. BParasites such as malaria
3. CGram-negative bacteria
4. DFungi such as Candida

Why is testing for HLA-B*15:02 recommended before carbamazepine in people of some Asian ancestries?

1. AIt greatly raises the risk of Stevens–Johnson syndrome
2. BThis gene variant speeds up the kidney excretion of carbamazepine
3. CThis gene variant makes carbamazepine ineffective
4. DThis gene variant causes carbamazepine to raise blood glucose

Пациентов, принимающих старые ингибиторы МАО, предупреждают о продуктах, богатых тирамином. Что может произойти?

1. AГипертонический криз
2. BТяжёлая гипогликемия
3. CАллергическая сыпь
4. DВнезапная почечная недостаточность

Which signs suggest early lithium toxicity?

1. APinpoint pupils and slow breathing
2. BDiarrhoea, vomiting, coarse tremor and drowsiness
3. CHair loss and dark urine only
4. DVery high blood pressure and a severe headache

A nurse gives 2 mg from a 4 mg ampoule of morphine. What should happen to the remaining 2 mg?

1. AIt is poured down the sink without telling anyone
2. BIt is kept labelled in the patient's drawer for the next dose
3. CIt is given to the next patient who needs morphine
4. DIt is discarded in front of a witness, and both sign the record

Why is clavulanic acid combined with amoxicillin (co-amoxiclav)?

1. AIt inhibits beta-lactamase enzymes that would destroy amoxicillin
2. BIt makes amoxicillin cross the blood–brain barrier more easily
3. CIt slows the kidney excretion of amoxicillin
4. DIt reduces the risk of penicillin allergy