ใบงาน เภสัชวิทยา พร้อมเฉลย

Celecoxib selectively inhibits which enzyme?

1. APhospholipase A2
2. BCyclo-oxygenase-1 (COX-1)
3. CCyclo-oxygenase-2 (COX-2)
4. DLipoxygenase

Propylthiouracil and carbimazole (or its active form methimazole, also called thiamazole) are used to treat which condition?

1. AAdrenal insufficiency
2. BType 1 diabetes
3. CHyperthyroidism
4. DHypothyroidism

Filgrastim, a granulocyte colony-stimulating factor (G-CSF), is given to:

1. AIncrease the production of platelets
2. BIncrease the production of neutrophils
3. CStop bleeding from wounds
4. DLower the white cell count in leukaemia

A patient with Addison's disease on hydrocortisone develops a fever with flu. What is the usual advice?

1. AIncrease the dose as instructed (sick-day rules) and seek help if vomiting
2. BHalve the hydrocortisone to reduce side effects
3. CMake no change, as illness does not affect cortisol needs
4. DStop the hydrocortisone until the fever settles, to let the body recover

A man taking tamsulosin is planning cataract surgery. What should the nurse advise?

1. ATell the eye surgeon, as it can cause floppy iris syndrome
2. BThe drug has no link with eye surgery
3. CStop the drug for one day and no further action is needed
4. DTake a double dose on the day of surgery

A 19-year-old starts an SSRI for depression. Which is most important for the nurse to monitor during the first weeks?

1. ABlood glucose before every meal and at bedtime
2. BHearing loss and tinnitus
3. CNew or worsening suicidal thoughts or agitation
4. DDaily bowel movements only

A patient with severe chronic hyponatraemia receives hypertonic saline. Why is the rate of correction strictly limited?

1. ARaising sodium too fast causes severe hypokalaemia and cardiac arrest
2. BRaising sodium too fast can cause osmotic demyelination in the brain
3. CHypertonic saline is toxic to the liver at high rates
4. DFast correction causes immediate kidney failure

Why are antipsychotics used with great caution in older people with dementia?

1. AThey cause severe hypoglycaemia in older people
2. BThey are linked to a higher risk of stroke and death
3. CThey always cure the dementia and stop all behaviour problems
4. DThey are not absorbed in people over 65