1.简单
What is the main effect of antidiuretic hormone (ADH) on the kidneys?
- AMore water is reabsorbed, so urine is concentrated
- BMore potassium is reabsorbed, so the serum potassium rises
- CMore water is excreted, so the urine becomes dilute
- DMore glucose is excreted, so the urine contains sugar
2.简单
药物的“峰”浓度测量的是什么?
- A药物产生毒性的水平
- B给药后的最高血药浓度
- C一周内的平均水平
- D下一次给药前的最低血药浓度
3.简单
成人血清钾的典型参考范围是多少?
- A6.0–8.0 mEq/L
- B3.5–5.0 mEq/L
- C135–145 mEq/L
- D1.3–2.1 mEq/L
4.中等
A patient with sepsis has a lactate of 2.1 mmol/L on admission and 4.3 mmol/L two hours later, despite IV fluids. What does this suggest?
- AA normal response to IV fluids in the first hours
- BImproving circulation as the fluids start to work
- CWorsening tissue perfusion that needs urgent reporting
- DExpected muscle activity from shivering in fever
5.中等
哪种治疗通过使钾进入细胞内来降低血清钾?
- A静脉注射普通胰岛素并配合葡萄糖
- B口服氯化钾补充剂
- C在 10 分钟内静脉注射葡萄糖酸钙
- D静脉输注 0.45% 氯化钠
6.中等
For most hospitalized adults with diabetes who are critically ill, which glucose target range is commonly recommended?
- AAbout 300–350 mg/dL (16.7–19.4 mmol/L)
- BAbout 140–180 mg/dL (7.8–10 mmol/L)
- CAbout 60–80 mg/dL (3.3–4.4 mmol/L)
- DAbout 250–300 mg/dL (13.9–16.7 mmol/L)
7.困难
A patient on stable digoxin starts amiodarone. A week later, the patient has nausea and visual changes, and the digoxin level is above the range. What is the most likely explanation?
- ADigoxin has raised the amiodarone level
- BAmiodarone has raised the digoxin level
- CThe patient has started a viral illness
- DAmiodarone has lowered potassium only
8.困难
A patient with a serum albumin of 1.9 g/dL (19 g/L) has signs of phenytoin toxicity, although the total phenytoin level is in the usual range. What is the most likely explanation?
- ALow albumin makes the liver clear phenytoin much faster
- BLow albumin makes the total level falsely high in all cases
- CLow albumin raises the free (active) fraction of phenytoin
- DLow albumin stops phenytoin from crossing into the brain
答案
- 1. A · More water is reabsorbed, so urine is concentrated
- 2. B · 给药后的最高血药浓度
- 3. B · 3.5–5.0 mEq/L
- 4. C · Worsening tissue perfusion that needs urgent reporting
- 5. A · 静脉注射普通胰岛素并配合葡萄糖
- 6. B · About 140–180 mg/dL (7.8–10 mmol/L)
- 7. B · Amiodarone has raised the digoxin level
- 8. C · Low albumin raises the free (active) fraction of phenytoin
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