1.简单
下列哪一项是药物代谢中典型的 II 相(结合)反应?
- A氧化
- B还原
- C葡萄糖醛酸化
- D水解
2.简单
Which description fits insulin glargine?
- AAn intermediate-acting cloudy insulin with a clear peak
- BA long-acting basal insulin with no marked peak
- CA rapid-acting insulin given with each meal
- DAn oral tablet that makes the pancreas release insulin
3.简单
Ciclosporin and tacrolimus are used mainly to:
- ATreat bacterial infections after surgery
- BLower high blood cholesterol
- CRelieve acute pain after surgery
- DPrevent rejection of transplanted organs
4.中等
After several years of levodopa treatment, which problem is common?
- ASevere hypoglycaemia after each dose
- BComplete and permanent loss of all Parkinson's symptoms
- CPermanent hearing loss
- DDyskinesias and "on–off" fluctuations in response
5.中等
How many micrograms are in 0.5 mg?
- A5000 micrograms
- B5 micrograms
- C500 micrograms
- D50 micrograms
6.中等
二甲双胍主要通过什么方式降低血糖?
- A阻断肾脏对葡萄糖的吸收
- B替代缺失的胰岛素
- C刺激胰腺释放胰岛素
- D减少肝脏葡萄糖的生成
7.困难
某药半衰期为 6 小时,血浆浓度为 80 mg/L。假设为一级消除且不再给药,18 小时后浓度是多少?
- A10 mg/L
- B26.7 mg/L
- C20 mg/L
- D40 mg/L
8.困难
A patient who has taken lorazepam daily for many months stops it suddenly. Which serious complication may follow?
- AWithdrawal seizures
- BPinpoint pupils and coma
- CProfound respiratory depression
- DSevere bradycardia
答案
- 1. C · 葡萄糖醛酸化
- 2. B · A long-acting basal insulin with no marked peak
- 3. D · Prevent rejection of transplanted organs
- 4. D · Dyskinesias and "on–off" fluctuations in response
- 5. C · 500 micrograms
- 6. D · 减少肝脏葡萄糖的生成
- 7. A · 10 mg/L
- 8. A · Withdrawal seizures
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